Accessible is an interesting concept. Entropy change is not happening just in a single reaction at moment in time, in one pass through a system, it is a cumulative process happening at all times with all energy transfer at all scales in all materials.

Too much energy in one place has a habit of not being contained, and damaging its container. Hence the difficulty of net fusion power output on earth, the stress on nuclear power systems, their cooling parts, control rods, chemical reactions, wearing away of parts, rust. Interesting to know that so much industrial infrastructure exists right now won’t be around in 100 years time, because it is made of concrete by methods not designed to make it last, most industrial stuff does not last. Energy Sceptic — As Energy Skeptic notes — https://energyskeptic.com/2021/enough-energy-left-to-rebuild-concrete-infrastructure/

30 to 50 year replacement times for so much of current infrastructure, energy machinery and critical parts, while the materials we used aren’t able to be reused easily, and the concentrated fossil fuel accessible energy that made it possible will be mostly used up.
Biological organisms and systems however, are made to reproduce themselves, constantly rebuild themselves while alive, cycle most materials, and run on comparatively ridiculous low amounts of energy density, supply and storage. This is because they are anti-entropy machines at every scale by design. Life processes have evolved to fight entropy at every single step. Only our high octane, high energy processes of materials and methods have not discovered how to implement these secrets. Nano-tech isn’t even close yet.